iAtheroSim 1.1
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Free Version
Publisher Description
Atherosclerosis, a pathology affecting arterial blood vessels, is one of most common diseases of developed countries. It is, in large part, due to the deposition of low density lipoproteins (LDL), i.e. plasma proteins carrying cholesterol and triglycerides that determine the formation of multiple plaques within the arteries [1]. The origin of atherosclerosis is still not fully understood. There are risk factors that increase the probability of developing atherosclerosis in humans. Some of these are within a person s control (smoking, obesity), while others seem to have a genetic origin (familial hypercholesterolemia, diabetes, hypertension) [2]. The common denominator in all forms of atherosclerosis is the elevated level of LDL, which is subject to oxidation, becoming oxidized LDL (oxLDL) that promotes inflammatory response and immune system activation in the artery walls [3]. The formation of atherosclerotic plaques in the artery reduces both the internal diameter of vessels and the blood flux, leading to a number of serious pathologies. Atherosclerosis and their anatomical consequences cause severe problems. Stenosis (narrowing) and aneurysm of the artery are chronic, progress slowly, and are the cumulative effects indicative of the progression of atherosclerotic disease. In both case the result is an insufficient blood supply to the organ fed by the artery. Most commonly, soft plaque suddenly ruptures, causes the formation of a thrombus that will rapidly slow or stop blood flow, leading to death of the tissues fed by the artery. This catastrophic event is called infarction and is not predictable. The most common event is thrombosis of the coronary artery causing infarction (a heart attack). However, since atherosclerosis is a body-wide process, similar events also occur in the arteries of the brain (stroke attack), intestines, kidneys, etc. Those atherosclerosis-associated events are often the cause of death or serious invalidate diseases and require preventive treatments. As atherosclerosis is recognized as an immune system-related pathology, recently we proposed a model based on the Agent Based Model (ABM) paradigm [4], which reproduces clinical and laboratory parameters associated to atherogenesis. The model and its computer implementation (SimAthero simulator) is accessible through the iAtheroSim iPhone application and produces as output the prediction on the risk of plaque formation at 6, 12 and 18 months, considering relevant personal parameters given by the user. References: [1] Hanson GK. 2002. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 352(16): 1685-95. [2] Romero-Corral A, Somers VK, Korinek J, et al. 2006. Update in prevention of atherosclerotic heart disease: management of major cardiovascular risk factors. Rev Invest Clin 58(3): 237-44. [3] Weber C, Zernecke A, Libby P. 2008. The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models. Nat Rev Immunol 8(10): 802-15. [4] Pappalardo F, Musumeci S, Motta S. 2008. Modeling immune system control of atherogenesis. Bioinformatics 24(15) 1715-21.
Requires iOS 4.0 or later. Compatible with iPhone, iPad, and iPod touch.
About iAtheroSim
iAtheroSim is a free app for iOS published in the Health & Nutrition list of apps, part of Home & Hobby.
The company that develops iAtheroSim is Bizmate S.r.l.. The latest version released by its developer is 1.1.
To install iAtheroSim on your iOS device, just click the green Continue To App button above to start the installation process. The app is listed on our website since 2011-06-14 and was downloaded 1 times. We have already checked if the download link is safe, however for your own protection we recommend that you scan the downloaded app with your antivirus. Your antivirus may detect the iAtheroSim as malware if the download link is broken.
How to install iAtheroSim on your iOS device:
- Click on the Continue To App button on our website. This will redirect you to the App Store.
- Once the iAtheroSim is shown in the iTunes listing of your iOS device, you can start its download and installation. Tap on the GET button to the right of the app to start downloading it.
- If you are not logged-in the iOS appstore app, you'll be prompted for your your Apple ID and/or password.
- After iAtheroSim is downloaded, you'll see an INSTALL button to the right. Tap on it to start the actual installation of the iOS app.
- Once installation is finished you can tap on the OPEN button to start it. Its icon will also be added to your device home screen.
